docosapentaenoate n3 DPA; 22:5n3 to Hexanoylcarnitine

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of hexanoylcarnitine (c6)
Metabolite Accession: GCST90199668
Name: hexanoylcarnitine (c6)
Hmdb Id: HMDB0000756
Super Pathway: NA
Sub Pathway: NA
Inchikey: VVPRQWTYSNDTEA

Associated Genomic Regions

Region: rs272893

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.151
Position:
131663062
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-9.708
Reference Allele:
C
-log10(P):
-49.632
MAF:
0.373
Beta (Num):
-0.058
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.093
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 SLC22A5 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

fatty acid metabolism4[1]

Denominator Metabolite Explanation:

Fatty acid metabolism, carnitine biosynthesis5[1], 6[2], 7[3]

Ratio Explanation:

The ratio may reflect carnitine-dependent fatty acid transport, where SLC22A5 variants could impair hexanoylcarnitine transport, impacting the availability of DPA for metabolism.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SLC22A4/SLC22A5 may alter carnitine and fatty acid transport, potentially influencing inflammatory processes and immune cell function, which could contribute to nasal polyp formation and observed changes in blood cell counts.8[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data