glutamine conjugate of c6h10o2 (2)* to linolenoylcarnitine (c18:3)*

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of linolenoylcarnitine (c18:3)*
Metabolite Accession: GCST90200132
Name: linolenoylcarnitine (c18:3)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Associated Genomic Regions

Region: rs270606

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.160
Position:
131650867
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-8.911
Reference Allele:
G
-log10(P):
-42.131
MAF:
0.295
Beta (Num):
-0.052
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.108
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Amino acid conjugation.

Denominator Metabolite Explanation:

Fatty acid transport, Fatty acid beta-oxidation.6[1], 7[2], 8[3]

Ratio Explanation:

The ratio likely reflects altered transport activity by SLC22A4/A5, where reduced carnitine transport (denominator) may co-occur with changes in the transport of other organic molecules (numerator).

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5 function likely impairs carnitine-dependent fatty acid oxidation, which can affect the development and function of hematopoietic cells, leading to observed variations in neutrophil, platelet, and other blood cell counts.9[1], 10[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data