linoleate (18:2n6) to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs635619

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
5
Beta (Ratio):
-0.125
Position:
131720265
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-8.607
Reference Allele:
G
-log10(P):
-39.432
MAF:
0.293
Beta (Num):
-0.033
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.092
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle

Ratio Explanation:

This ratio reflects the balance between available linoleate and its mitochondrial transport for oxidation, which is dependent on carnitine transported by SLC22A5.2[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired SLC22A5 function reduces carnitine uptake, decreasing palmitoleoylcarnitine formation and altering the ratio.2[1], 5[2] This disruption of fatty acid oxidation and cellular energy can impact the development and function of neutrophils, platelets, and other blood cells, leading to the observed hematological phenotypes.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data