dihomo-linolenate (20:3n3 or n6) to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs61896141

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
11
Beta (Ratio):
0.203
Position:
61556039
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
9.887
Reference Allele:
A
-log10(P):
-51.402
MAF:
0.179
Beta (Num):
0.149
Novel Locus:
No
SE (Num):
0.020
Beta (Den):
-0.054
SE (Den):
0.020
No CNV overlap
rQTL cluster:
62
Reaction Distance:
NA
Closest Genes:
TMEM258 MYRF FEN1 FADS2 FADS1

Region: rs272855

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
5
Beta (Ratio):
-0.182
Position:
131687175
SE (Ratio):
0.017
Effect Allele:
C
Z-score (Ratio):
-10.638
Reference Allele:
T
-log10(P):
-59.182
MAF:
0.293
Beta (Num):
-0.052
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.130
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 C5orf56 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation7[1], 8[2]

Ratio Explanation:

This ratio may reflect the balance between polyunsaturated fatty acid synthesis (numerator) and fatty acid breakdown for energy (denominator), influenced by FADS1/FADS2 activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in FADS1/FADS2 influence the efficiency of dihomo-linolenate synthesis.9[1], 10[2] Altered levels of this fatty acid and its derivatives could impact inflammatory responses, potentially contributing to inflammatory skin conditions like seborrhoeic and infective dermatitis, and sinusitis through modulation of eicosanoid production.11[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data