dihomo-linoleate (20:2n6) to 3-hydroxyoleoylcarnitine

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Associated Genomic Regions

Region: rs10076701

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.152
Position:
131596419
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
-10.154
Reference Allele:
C
-log10(P):
-54.105
MAF:
0.445
Beta (Num):
-0.033
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.119
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
PDLIM4 P4HA2 SLC22A4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, linoleic acid metabolism.7[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio may reflect altered fatty acid metabolism and transport. SLC22A4 transports carnitine, which is essential for fatty acid transport into mitochondria for beta-oxidation.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Altered SLC22A4 function likely impacts fatty acid transport via its role as a low-affinity carnitine transporter, and its primary role as an ergothioneine transporter influences inflammatory responses, contributing to gout and affecting neutrophil and uric acid levels.1[1], 2[2], 5[3], 6[4]

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data