glutamine conjugate of c6h10o2 (2)* to myristoylcarnitine (c14)

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs4705857

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.168
Position:
131737030
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
-9.563
Reference Allele:
C
-log10(P):
-48.215
MAF:
0.313
Beta (Num):
-0.055
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.113
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 IRF1 P4HA2

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Glutamine conjugation

Denominator Metabolite Explanation:

Fatty acid metabolism, Carnitine shuttle.4[1], 5[2], 6[3]

Ratio Explanation:

The ratio likely reflects the activity of the SLC22A5 transporter, which imports the denominator myristoylcarnitine and may also transport the numerator glutamine conjugate.1[1], 7[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

SLC22A5 variants alter carnitine transport, affecting fatty acid metabolism and potentially xenobiotic clearance.1[1], 8[2] This systemic metabolic disruption likely influences hematopoietic cell production and liver function, leading to observed changes in blood cell counts and bilirubin.9[3], 10[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data