acetylcarnitine (c2) to palmitoleate (16:1n7)

Numerator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs419291

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.143
Position:
131633355
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
9.972
Reference Allele:
C
-log10(P):
-52.260
MAF:
0.372
Beta (Num):
0.112
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.031
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, beta-oxidation.8[1], 9[2]

Ratio Explanation:

The ratio may reflect altered carnitine-dependent fatty acid oxidation, where SLC22A5 dysfunction impacts acetylcarnitine levels and the metabolism of fatty acids like palmitoleate.1[1], 2[2], 5[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variants in SLC22A5 can impair carnitine transport, altering fatty acid metabolism. This may affect the function and development of hematopoietic cells, leading to changes in neutrophil and other blood cell counts.1[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data