docosapentaenoate (n6 dpa; 22:5n6) to myristoylcarnitine (c14)

Numerator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Denominator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs270615

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.177
Position:
131641573
SE (Ratio):
0.018
Effect Allele:
G
Z-score (Ratio):
-9.862
Reference Allele:
C
-log10(P):
-51.152
MAF:
0.291
Beta (Num):
-0.060
Novel Locus:
No
SE (Num):
0.018
Beta (Den):
0.117
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Omega-6 fatty acid biosynthesis/metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine transport.7[1], 8[2], 9[3]

Ratio Explanation:

Impaired SLC22A5 function reduces myristoylcarnitine (denominator) formation due to decreased carnitine transport, potentially altering the balance of fatty acids like docosapentaenoate (numerator).

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 transporter function alters cellular carnitine levels, impacting fatty acid oxidation and leading to a systemic metabolic shift.1[1], 2[2] This dysfunction may affect the maturation and count of hematopoietic cells, such as monocytes and lymphocytes, which are sensitive to metabolic and inflammatory states.10[3], 11[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data