oleate/vaccenate (18:1) to 3-hydroxyoleoylcarnitine

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Associated Genomic Regions

Region: rs419291

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.145
Position:
131633355
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
-9.470
Reference Allele:
C
-log10(P):
-47.323
MAF:
0.371
Beta (Num):
-0.035
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.110
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism.3[1], 4[2], 5[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Ratio Explanation:

The ratio reflects carnitine-dependent fatty acid transport and oxidation; a higher ratio may suggest impaired mitochondrial uptake or beta-oxidation of oleate.

Ratio Evidence:

reaction where the ratio is shared through a pathway

Gene Ratio Phenotype Relationship:

Variations in the SLC22A5/SLC22A4 carnitine transporters alter fatty acid oxidation efficiency. This impacts energy metabolism and inflammatory responses, plausibly affecting hematological traits like neutrophil counts8[1], 9[2], and metabolic parameters like uric acid levels10[3], 11[4] due to the transporters' broad substrate specificity and role in cellular homeostasis.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data