adrenate (22:4n6) to 3-hydroxyoleoylcarnitine

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Associated Genomic Regions

Region: rs10076701

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.158
Position:
131596419
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-10.072
Reference Allele:
C
-log10(P):
-53.267
MAF:
0.445
Beta (Num):
-0.040
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.119
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
PDLIM4 P4HA2 SLC22A4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle8[1], 9[2], 10[3]

Ratio Explanation:

This ratio may reflect carnitine-dependent fatty acid oxidation efficiency. Decreased SLC22A4/5 function can impair carnitine transport, affecting the denominator (3-hydroxyoleoylcarnitine), a beta-oxidation intermediate.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the transporter SLC22A4 affects its function, which has been directly linked to altered uric acid levels and gout.4[1], 11[2] The ratio of adrenate to 3-hydroxyoleoylcarnitine likely reflects downstream effects on fatty acid and carnitine metabolism due to this primary transporter defect.

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data