linoleate (18:2n6) to acetylcarnitine (c2)

Numerator Metabolite

Structure of linoleate (18:2n6)
Metabolite Accession: GCST90200354
Name: linoleate (18:2n6)
Hmdb Id: HMDB0006270,HMDB0000673
Super Pathway: NA
Sub Pathway: NA
Inchikey: OYHQOLUKZRVURQ

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs419291

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.149
Position:
131633355
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
-9.998
Reference Allele:
C
-log10(P):
-52.515
MAF:
0.372
Beta (Num):
-0.036
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.112
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation/metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid transport/carnitine shuttle.7[1], 8[2]

Ratio Explanation:

Reflects efficiency of carnitine-dependent fatty acid oxidation, potentially modulated by SLC22A5-mediated carnitine uptake which affects both linoleate metabolism and acetylcarnitine levels.3[1], 9[2], 10[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

SLC22A5 genetic variants likely alter carnitine transport, affecting systemic fatty acid oxidation. This metabolic disruption could impact hematopoietic cell proliferation and function, leading to observed changes in monocyte, platelet, and other blood cell counts.11[1], 12[2], 13[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data