oleoylcarnitine (c18:1) to Docosahexaenoate DHA; 22:6n3

Numerator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of docosahexaenoate (dha; 22:6n3)
Metabolite Accession: GCST90199651
Name: docosahexaenoate (dha; 22:6n3)
Hmdb Id: HMDB0002183
Super Pathway: NA
Sub Pathway: NA
Inchikey: MBMBGCFOFBJSGT

Associated Genomic Regions

Region: rs273903

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.175
Position:
131692462
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
9.818
Reference Allele:
G
-log10(P):
-50.712
MAF:
0.294
Beta (Num):
0.130
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.045
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid biosynthesis7[1], 8[2]

Ratio Explanation:

The ratio may reflect cellular carnitine transport efficiency by SLC22A5 and SLC22A4, impacting fatty acid metabolism.1[1], 5[2], 2[3], 9[4] Altered transport could affect both metabolites.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5/SLC22A4 function likely modifies carnitine-dependent fatty acid metabolism and transport of ergothioneine, an antioxidant important for hematopoietic cell differentiation and protection from oxidative stress.10[1], 11[2], 12[3], 13[4] This dysregulation could plausibly influence the development and counts of various blood cell lineages, including monocytes, platelets, and lymphocytes.14[5]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data