ergothioneine to arachidoylcarnitine (c20)*

Numerator Metabolite

Structure of ergothioneine
Metabolite Accession: GCST90199879
Name: ergothioneine
Hmdb Id: HMDB0003045
Super Pathway: NA
Sub Pathway: NA
Inchikey: SSISHJJTAXXQAX

Denominator Metabolite

Structure of arachidoylcarnitine (c20)*
Metabolite Accession: GCST90200135
Name: arachidoylcarnitine (c20)*
Hmdb Id: HMDB0006460
Super Pathway: NA
Sub Pathway: NA
Inchikey: SVJLJQBGUITFLI

Associated Genomic Regions

Region: rs10075801

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.260
Position:
131677642
SE (Ratio):
0.022
Effect Allele:
G
Z-score (Ratio):
11.664
Reference Allele:
A
-log10(P):
-70.717
MAF:
0.473
Beta (Num):
0.138
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
-0.122
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Ergothioneine biosynthesis7[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid metabolism/beta-oxidation1[1], 9[2], 10[3], 11[4]

Ratio Explanation:

The ratio may reflect the balance between ergothioneine uptake and carnitine-dependent fatty acid oxidation, regulated by the transporters SLC22A4 and SLC22A5.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered function of the co-regulated transporters SLC22A4/SLC22A5 likely impacts both ergothioneine and carnitine levels, potentially influencing inflammatory pathways and energy metabolism, which are linked to the diverse associated phenotypes including glaucoma, skin cancer, hypertension, and asthma.5[1], 12[2], 6[3]

Phenotype Driver:

Gene-centric:SLC22A4/SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data