arachidonate (20:4n6) to acetylcarnitine (c2)

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs6897575

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.171
Position:
131604535
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
-10.562
Reference Allele:
T
-log10(P):
-58.368
MAF:
0.436
Beta (Num):
-0.060
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.111
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
PDLIM4 P4HA2 SLC22A4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Eicosanoid synthesis, fatty acid metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.8[1], 9[2], 10[3]

Ratio Explanation:

The ratio may reflect a balance between proinflammatory precursor availability (arachidonate) and fatty acid oxidation efficiency (indicated by acetylcarnitine).

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A4/SLC22A5 function can impair carnitine-dependent fatty acid oxidation and is also genetically associated with altered uric acid levels and gout.11[1], 12[2], 13[3], 14[4] The ratio may reflect metabolic dysregulation, including inflammation and altered energy utilization, contributing to the gout phenotype.

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data