docosapentaenoate n3 DPA; 22:5n3 to linolenoylcarnitine (c18:3)*

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of linolenoylcarnitine (c18:3)*
Metabolite Accession: GCST90200132
Name: linolenoylcarnitine (c18:3)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Associated Genomic Regions

Region: rs2516788

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.158
Position:
131715565
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-8.984
Reference Allele:
G
-log10(P):
-42.790
MAF:
0.372
Beta (Num):
-0.061
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.098
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis4[1], 5[2]

Denominator Metabolite Explanation:

Carnitine shuttle, Fatty acid beta-oxidation1[1], 6[2]

Ratio Explanation:

The ratio reflects carnitine-dependent fatty acid transport versus omega-3 fatty acid synthesis.1[1], 4[2] SLC22A5 variants may alter carnitine transport, affecting the denominator.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the SLC22A4/A5 locus are associated with altered transporter function, impacting both carnitine-dependent fatty acid metabolism and uric acid handling.7[1], 8[2], 9[3] This dual effect likely connects the metabolic ratio to gout and related inflammatory/hematological phenotypes.

Phenotype Driver:

Gene-centric:SLC22A5/SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data