adrenate (22:4n6) to Hexanoylcarnitine

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of hexanoylcarnitine (c6)
Metabolite Accession: GCST90199668
Name: hexanoylcarnitine (c6)
Hmdb Id: HMDB0000756
Super Pathway: NA
Sub Pathway: NA
Inchikey: VVPRQWTYSNDTEA

Associated Genomic Regions

Region: rs274556

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.149
Position:
131722075
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
-9.125
Reference Allele:
A
-log10(P):
-44.082
MAF:
0.294
Beta (Num):
-0.053
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.095
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis5[1]

Denominator Metabolite Explanation:

Fatty acid metabolism6[1]

Ratio Explanation:

A decreased ratio of adrenate to hexanoylcarnitine may indicate increased beta-oxidation, potentially influenced by ACADM activity, where hexanoylcarnitine is a substrate.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The ACADM gene's role in fatty acid oxidation directly impacts energy metabolism. Altered ACADM function, reflected in the adrenate to hexanoylcarnitine ratio, may influence the availability of energy substrates for hematopoietic cell proliferation and differentiation, thus affecting neutrophil, platelet, and other blood cell counts.7[1], 8[2]

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data