dihomo-linoleate (20:2n6) to Hexanoylcarnitine

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of hexanoylcarnitine (c6)
Metabolite Accession: GCST90199668
Name: hexanoylcarnitine (c6)
Hmdb Id: HMDB0000756
Super Pathway: NA
Sub Pathway: NA
Inchikey: VVPRQWTYSNDTEA

Associated Genomic Regions

Region: rs272893

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.136
Position:
131663062
SE (Ratio):
0.015
Effect Allele:
T
Z-score (Ratio):
-9.190
Reference Allele:
C
-log10(P):
-44.683
MAF:
0.373
Beta (Num):
-0.043
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.093
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 SLC22A5 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Alpha-linolenic and linoleic acid metabolism.3[1]

Denominator Metabolite Explanation:

Fatty acid metabolism (beta-oxidation).2[1], 4[2]

Ratio Explanation:

This ratio may reflect a metabolic shift where impaired medium-chain fatty acid beta-oxidation, evidenced by higher hexanoylcarnitine, occurs alongside alterations in long-chain fatty acid metabolism.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in ACADM can impair its enzymatic function, leading to altered levels of hexanoylcarnitine and metabolic dysregulation that may systemically affect hematopoiesis, resulting in the observed associations with neutrophil, platelet, and other blood cell counts.

Phenotype Driver:

Gene-centric:ACADM

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data