oleate/vaccenate (18:1) to acetylcarnitine (c2)

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs419291

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.147
Position:
131633355
SE (Ratio):
0.014
Effect Allele:
T
Z-score (Ratio):
-10.385
Reference Allele:
C
-log10(P):
-56.499
MAF:
0.371
Beta (Num):
-0.035
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.112
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
7.0
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis4[1], 5[2], 6[3] and beta-oxidation.7[4], 8[5]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation9[1], 10[2], 11[3] and amino acid metabolism.10[4]

Ratio Explanation:

An elevated ratio may indicate decreased carnitine-dependent transport of fatty acids into mitochondria, potentially due to reduced SLC22A5 function, leading to lower acetylcarnitine production.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair fatty acid oxidation in immune cells like monocytes, affecting their differentiation and function, which may lead to altered blood cell counts.12[1], 13[2], 14[3], 15[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data