palmitoleoylcarnitine (c16:1)* to 5-dodecenoate (12:1n7)

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of 5-dodecenoate (12:1n7)
Metabolite Accession: GCST90199723
Name: 5-dodecenoate (12:1n7)
Hmdb Id: HMDB0000529
Super Pathway: NA
Sub Pathway: NA
Inchikey: IJBFSOLHRKELLR

Associated Genomic Regions

Region: rs2130525

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Clumped rQTL variant

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SNP Summary

Chr:
1
Beta (Ratio):
0.122
Position:
151902101
SE (Ratio):
0.011
Effect Allele:
T
Z-score (Ratio):
10.870
Reference Allele:
C
-log10(P):
-61.694
MAF:
0.392
Beta (Num):
0.053
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
-0.069
SE (Den):
0.015
No CNV overlap
rQTL cluster:
155
Reaction Distance:
NA
Closest Genes:
THEM4 S100A10 THEM5 C2CD4D RORC

Region: rs388891

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.109
Position:
131700794
SE (Ratio):
0.012
Effect Allele:
C
Z-score (Ratio):
9.086
Reference Allele:
G
-log10(P):
-43.718
MAF:
0.295
Beta (Num):
0.092
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.018
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid transport and beta-oxidation.5[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Ratio Explanation:

This ratio may reflect carnitine-dependent transport efficiency via SLC22A5, comparing long-chain palmitoleoylcarnitine levels to the medium-chain fatty acid 5-dodecenoate pool.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the carnitine transporter SLC22A5 likely alters fatty acid metabolism, reflected by the ratio. This dysregulation of energy substrates can impact hematopoiesis and immune cell function, leading to the observed associations with neutrophil, platelet, and other blood cell counts.8[1], 9[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data