adrenate (22:4n6) to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of adrenate (22:4n6)
Metabolite Accession: GCST90199709
Name: adrenate (22:4n6)
Hmdb Id: HMDB0002226
Super Pathway: NA
Sub Pathway: NA
Inchikey: TWSWSIQAPQLDBP

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs273917

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.146
Position:
131659618
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-10.252
Reference Allele:
G
-log10(P):
-55.115
MAF:
0.294
Beta (Num):
-0.054
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.091
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 SLC22A5 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis3[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle4[1], 5[2]

Ratio Explanation:

This ratio compares adrenate to palmitoleoylcarnitine, an acylcarnitine. Reduced SLC22A5 function impairs carnitine transport, decreasing fatty acid oxidation and potentially increasing this ratio.6[1], 1[2], 5[3]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function impairs carnitine-dependent fatty acid oxidation, which is critical for energy production in immune cells.6[1], 1[2], 4[3] This metabolic disruption likely contributes to the observed alterations in monocyte and other blood cell counts.7[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data