oleoylcarnitine (c18:1) to 10-heptadecenoate (17:1n7)

Numerator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 10-heptadecenoate (17:1n7)
Metabolite Accession: GCST90199731
Name: 10-heptadecenoate (17:1n7)
Hmdb Id: HMDB0060038
Super Pathway: NA
Sub Pathway: NA
Inchikey: GDTXICBNEOEPAZ

Associated Genomic Regions

Region: rs272855

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.161
Position:
131687175
SE (Ratio):
0.016
Effect Allele:
C
Z-score (Ratio):
10.320
Reference Allele:
T
-log10(P):
-55.816
MAF:
0.294
Beta (Num):
0.130
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.031
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 C5orf56 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid metabolism.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio may reflect carnitine transporter (SLC22A5) activity, comparing a carnitine-dependent fatty acid (oleoylcarnitine) to a free monounsaturated fatty acid (10-heptadecenoate).

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the carnitine transporter SLC22A5 likely alters carnitine-dependent fatty acid metabolism, reflected in the ratio.10[1], 11[2] This systemic effect on energy homeostasis can impact the function of hematopoietic and immune cells, influencing various blood cell counts, including neutrophils and platelets.12[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data