eicosapentaenoate (epa; 20:5n3) to docosahexaenoylcarnitine (c22:6)*

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Metabolite Accession: GCST90200146
Name: docosahexaenoylcarnitine (c22:6)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs270607

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.173
Position:
131649186
SE (Ratio):
0.018
Effect Allele:
A
Z-score (Ratio):
-9.342
Reference Allele:
G
-log10(P):
-46.109
MAF:
0.302
Beta (Num):
-0.059
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.114
SE (Den):
0.019
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid metabolism.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation and carnitine transport.7[1], 8[2]

Ratio Explanation:

This ratio compares a free omega-3 fatty acid (EPA) to a carnitine-conjugated omega-3 (DHA-carnitine), potentially reflecting carnitine-dependent fatty acid transport influenced by SLC22A5.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in the carnitine transporter SLC22A5 alter carnitine homeostasis, affecting the ratio of free to carnitine-conjugated omega-3 fatty acids.1[1], 9[2] This disruption in fatty acid metabolism may impact hematopoietic cell functions, leading to observed alterations in monocyte, platelet, and other blood cell counts.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data