docosapentaenoate n3 DPA; 22:5n3 to myristoleoylcarnitine (c14:1)*

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Associated Genomic Regions

Region: rs441969

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.126
Position:
131702120
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-8.834
Reference Allele:
A
-log10(P):
-41.438
MAF:
0.376
Beta (Num):
-0.058
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.068
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid metabolism.5[1], 6[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.7[1], 8[2]

Ratio Explanation:

The ratio reflects carnitine-dependent fatty acid breakdown, influenced by the SLC22A5 transporter, relative to omega-3 fatty acid levels, indicating a metabolic balance.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variants in the carnitine transporter SLC22A5 may alter fatty acid metabolism, influencing inflammatory processes and hematopoietic cell counts. This could create a predisposition to conditions like nasal polyps and cause observed changes in blood cell-related phenotypes.3[1], 9[2], 10[3], 11[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data