arachidonate (20:4n6) to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs272880

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.156
Position:
131670178
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
-10.132
Reference Allele:
T
-log10(P):
-53.876
MAF:
0.294
Beta (Num):
-0.065
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.091
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Eicosanoid synthesis, prostaglandin and leukotriene metabolism.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.6[1], 7[2], 8[3]

Ratio Explanation:

This ratio may reflect cellular energy status and inflammation, influenced by SLC22A5-mediated carnitine transport for fatty acid oxidation versus arachidonate's role in inflammatory pathways.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair carnitine-dependent fatty acid oxidation in immune cells, altering energy availability and potentially leading to the observed changes in neutrophil, eosinophil, monocyte, lymphocyte, and platelet counts, which are associated with systemic carnitine deficiency.9[1]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data