docosapentaenoate n3 DPA; 22:5n3 to (r)-3-hydroxybutyrylcarnitine

Numerator Metabolite

Structure of docosapentaenoate (n3 dpa; 22:5n3)
Metabolite Accession: GCST90199713
Name: docosapentaenoate (n3 dpa; 22:5n3)
Hmdb Id: HMDB0006528
Super Pathway: NA
Sub Pathway: NA
Inchikey: YUFFSWGQGVEMMI

Denominator Metabolite

Structure of (r)-3-hydroxybutyrylcarnitine
Metabolite Accession: GCST90199930
Name: (r)-3-hydroxybutyrylcarnitine
Hmdb Id: HMDB0013127
Super Pathway: NA
Sub Pathway: NA
Inchikey: UEFRDQSMQXDWTO

Associated Genomic Regions

Region: rs10076701

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.138
Position:
131596419
SE (Ratio):
0.017
Effect Allele:
T
Z-score (Ratio):
-8.212
Reference Allele:
C
-log10(P):
-36.060
MAF:
0.445
Beta (Num):
-0.052
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.086
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
PDLIM4 P4HA2 SLC22A4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Omega-3 fatty acid biosynthesis/metabolism.7[1], 8[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, ketone body metabolism.9[1], 10[2], 11[3]

Ratio Explanation:

The ratio reflects a balance between omega-3 fatty acid levels and carnitine-dependent fatty acid/ketone metabolism, which is influenced by SLC22A4/A5 transporter function.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

SLC22A4/A5 variants impact both carnitine-dependent lipid metabolism (the ratio) and renal urate transport.3[1], 5[2], 12[3] This dual role provides a causal link to the associated phenotypes of altered blood cell counts, high uric acid, and gout.

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data