arachidonate (20:4n6) to (r)-3-hydroxybutyrylcarnitine

Numerator Metabolite

Structure of arachidonate (20:4n6)
Metabolite Accession: GCST90200358
Name: arachidonate (20:4n6)
Hmdb Id: HMDB0001043
Super Pathway: NA
Sub Pathway: NA
Inchikey: YZXBAPSDXZZRGB

Denominator Metabolite

Structure of (r)-3-hydroxybutyrylcarnitine
Metabolite Accession: GCST90199930
Name: (r)-3-hydroxybutyrylcarnitine
Hmdb Id: HMDB0013127
Super Pathway: NA
Sub Pathway: NA
Inchikey: UEFRDQSMQXDWTO

Associated Genomic Regions

Region: rs7727038

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.143
Position:
131590257
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-8.001
Reference Allele:
T
-log10(P):
-34.330
MAF:
0.445
Beta (Num):
-0.057
Novel Locus:
Yes ✔️
SE (Num):
0.015
Beta (Den):
0.086
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
P4HA2 PDLIM4 SLC22A4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Arachidonic acid metabolism, Eicosanoid signaling.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Ketone body metabolism.8[1], 9[2]

Ratio Explanation:

The ratio may reflect a balance between proinflammatory arachidonate signaling and cellular carnitine uptake for fatty acid oxidation, mediated by SLC22A4/5 transporters.3[1], 5[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

The SLC22A4 gene, a transporter for organic cations like carnitine, is genetically associated with gout and regulates uric acid levels.10[1], 11[2], 2[3], 4[4] Altered transporter function could influence both carnitine-dependent fatty acid metabolism and urate excretion, leading to the observed phenotype.

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data