3-hydroxyoleoylcarnitine to glutamine conjugate of c7h12o2*

Numerator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Denominator Metabolite

Metabolite Accession: GCST90200167
Name: glutamine conjugate of c7h12o2*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs272857

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.159
Position:
131685297
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
10.140
Reference Allele:
A
-log10(P):
-53.963
MAF:
0.374
Beta (Num):
0.108
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.051
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 C5orf56 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Glutamine metabolism, Xenobiotic metabolism

Ratio Explanation:

The ratio reflects the balance between fatty acid transport by SLC22A5 (numerator) and a detoxification or amino acid metabolism pathway (denominator).

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

The SLC22A5 gene, a carnitine transporter, influences both fatty acid metabolism and immune cell function.1[1], 5[2], 6[3] Its activity, reflected in the acylcarnitine level, likely affects the availability of energy substrates for hematopoietic cells, thus impacting monocyte and other blood cell counts.7[4], 8[5]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data