palmitoleoylcarnitine (c16:1)* to palmitoleate (16:1n7)

Numerator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs273917

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.121
Position:
131659618
SE (Ratio):
0.012
Effect Allele:
A
Z-score (Ratio):
10.393
Reference Allele:
G
-log10(P):
-56.584
MAF:
0.295
Beta (Num):
0.091
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
-0.030
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 SLC22A5 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.6[1]

Denominator Metabolite Explanation:

Fatty acid biosynthesis, beta-oxidation.7[1], 8[2]

Ratio Explanation:

The ratio reflects carnitine-dependent transport of palmitoleate into mitochondria, a process reliant on the carnitine transporter protein SLC22A5.1[1], 2[2], 6[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can impair carnitine transport, affecting fatty acid oxidation in hematopoietic stem cells and leading to altered blood cell counts, which are among the observed phenotypes.9[1], 10[2], 11[3], 12[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data