docosapentaenoate (n6 dpa; 22:5n6) to acetylcarnitine (c2)

Numerator Metabolite

Structure of docosapentaenoate (n6 dpa; 22:5n6)
Metabolite Accession: GCST90199796
Name: docosapentaenoate (n6 dpa; 22:5n6)
Hmdb Id: HMDB0001976
Super Pathway: NA
Sub Pathway: NA
Inchikey: AVKOENOBFIYBSA

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs274546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.165
Position:
131699867
SE (Ratio):
0.017
Effect Allele:
A
Z-score (Ratio):
-9.827
Reference Allele:
G
-log10(P):
-50.807
MAF:
0.373
Beta (Num):
-0.053
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.112
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis and metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation and carnitine shuttle.8[1], 9[2], 10[3], 11[4]

Ratio Explanation:

The ratio likely reflects a balance between long-chain fatty acid availability and carnitine-dependent metabolism, which is directly influenced by the SLC22A5 transporter.1[1], 4[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SLC22A5 can impair carnitine transport, altering the cellular fatty acid/acylcarnitine balance, which is reflected in the ratio.1[1], 4[2] This dysregulation of energy metabolism and lipid homeostasis likely impacts hematopoiesis and inflammatory cell function, leading to the observed variations in blood cell counts.12[3], 13[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data