lignoceroylcarnitine (c24)* to tryptophan betaine

Numerator Metabolite

Structure of lignoceroylcarnitine (c24)*
Metabolite Accession: GCST90200137
Name: lignoceroylcarnitine (c24)*
Hmdb Id: HMDB0240665
Super Pathway: NA
Sub Pathway: NA
Inchikey: YDUFZFUYBBPVLJ

Denominator Metabolite

Structure of tryptophan betaine
Metabolite Accession: GCST90199819
Name: tryptophan betaine
Hmdb Id: HMDB0061115
Super Pathway: NA
Sub Pathway: NA
Inchikey: AOHCBEAZXHZMOR

Associated Genomic Regions

Region: rs11743851

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.185
Position:
130613600
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-10.295
Reference Allele:
T
-log10(P):
-55.561
MAF:
0.382
Beta (Num):
-0.091
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.094
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
CDC42SE2 LYRM7 HINT1 RAPGEF6 CTC-432M15.3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2]

Denominator Metabolite Explanation:

Tryptophan metabolism.7[1], 8[2]

Ratio Explanation:

The ratio may reflect altered cellular energy and inflammatory states, as *SLC22A4* transports organic cations and is linked to inflammatory diseases, while lignoceroylcarnitine is involved in fatty acid oxidation and tryptophan betaine has anti-inflammatory properties.2[1], 5[2], 9[3], 10[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced *SLC22A4* function could alter the transport of tryptophan betaine and other cations, impacting inflammatory pathways. This, combined with changes in fatty acid metabolism indicated by lignoceroylcarnitine levels, may contribute to the chronic inflammation seen in phenotypes like Crohn's disease and ulcerative colitis.11[1], 1[2], 2[3]

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data