branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid* to 3-hydroxyoleoylcarnitine

Numerator Metabolite

Metabolite Accession: GCST90200249
Name: branched-chain, straight-chain, or cyclopropyl 12:1 fatty acid*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Associated Genomic Regions

Region: rs162892

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.146
Position:
131623250
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-9.461
Reference Allele:
G
-log10(P):
-47.238
MAF:
0.324
Beta (Num):
-0.026
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.120
SE (Den):
0.017
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
P4HA2 SLC22A4 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis5[1], 6[2], 7[3], 8[4]

Denominator Metabolite Explanation:

Carnitine shuttle/Fatty acid metabolism1[1], 9[2], 10[3], 11[4]

Ratio Explanation:

This ratio may reflect altered fatty acid metabolism, where SLC22A5 variants could impact carnitine-dependent transport of fatty acids, affecting both metabolite pools.2[1], 9[2]

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can lead to impaired fatty acid oxidation and carnitine deficiency, potentially impacting cellular processes that influence traits like height and neutrophil count.12[1], 13[2], 14[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data