tetradecadienoate (14:2)* to acetylcarnitine (c2)

Numerator Metabolite

Structure of tetradecadienoate (14:2)*
Metabolite Accession: GCST90200187
Name: tetradecadienoate (14:2)*
Hmdb Id: HMDB0000560
Super Pathway: NA
Sub Pathway: NA
Inchikey: HXHZGHRLVRFQDR

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs272849

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.135
Position:
131690241
SE (Ratio):
0.014
Effect Allele:
A
Z-score (Ratio):
-9.601
Reference Allele:
G
-log10(P):
-48.585
MAF:
0.374
Beta (Num):
-0.022
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.112
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.6[1], 7[2], 8[3]

Denominator Metabolite Explanation:

Fatty acid and amino acid metabolism.9[1]

Ratio Explanation:

A decreased ratio may indicate impaired carnitine transport by SLC22A5, leading to reduced fatty acid oxidation and an accumulation of tetradecadienoate relative to acetylcarnitine.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function can lead to systemic carnitine deficiency, affecting fatty acid metabolism in immune cells and potentially altering immune cell counts, including neutrophils, as observed in the associated phenotypes.10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data