10-undecenoate (11:1n1) to myristoylcarnitine (c14)

Numerator Metabolite

Structure of 10-undecenoate (11:1n1)
Metabolite Accession: GCST90199716
Name: 10-undecenoate (11:1n1)
Hmdb Id: HMDB0033724
Super Pathway: NA
Sub Pathway: NA
Inchikey: FRPZMMHWLSIFAZ

Denominator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs270614

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.159
Position:
131640813
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
-9.780
Reference Allele:
A
-log10(P):
-50.342
MAF:
0.292
Beta (Num):
-0.042
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.117
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism.5[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.6[1], 7[2], 8[3]

Ratio Explanation:

Reduced SLC22A5 function decreases myristoylcarnitine (denominator) formation and may alter fatty acid (numerator) levels, reflecting impaired carnitine-dependent fatty acid transport and metabolism.2[1], 9[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function alters carnitine-dependent fatty acid oxidation, the primary energy source for many cells, including hematopoietic ones. This metabolic disruption likely impacts the production and turnover of neutrophils, platelets, and other blood cells, leading to the observed count variations.10[1], 11[2], 12[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data