oleoylcarnitine (c18:1) to palmitoleate (16:1n7)

Numerator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitoleate (16:1n7)
Metabolite Accession: GCST90200388
Name: palmitoleate (16:1n7)
Hmdb Id: HMDB0003229
Super Pathway: NA
Sub Pathway: NA
Inchikey: SECPZKHBENQXJG

Associated Genomic Regions

Region: rs388891

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.159
Position:
131700794
SE (Ratio):
0.015
Effect Allele:
C
Z-score (Ratio):
10.429
Reference Allele:
G
-log10(P):
-56.962
MAF:
0.295
Beta (Num):
0.130
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.029
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, Carnitine shuttle3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid biosynthesis5[1], 6[2]

Ratio Explanation:

The ratio of oleoylcarnitine to palmitoleate likely reflects the activity of SLC22A5-mediated carnitine transport required for the mitochondrial import and subsequent beta-oxidation of fatty acids.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function may alter fatty acid metabolism and transport. Since RUNX1, a key hematopoietic transcription factor, has been linked to SLC22A4/5 regulation, this suggests a potential mechanism for influencing blood cell counts, including monocytes and lymphocytes.7[1], 8[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data