histidine betaine (hercynine)* to arachidoylcarnitine (c20)*

Numerator Metabolite

Structure of histidine betaine (hercynine)*
Metabolite Accession: GCST90199927
Name: histidine betaine (hercynine)*
Hmdb Id: HMDB0029422
Super Pathway: NA
Sub Pathway: NA
Inchikey: GPPYTCRVKHULJH

Denominator Metabolite

Structure of arachidoylcarnitine (c20)*
Metabolite Accession: GCST90200135
Name: arachidoylcarnitine (c20)*
Hmdb Id: HMDB0006460
Super Pathway: NA
Sub Pathway: NA
Inchikey: SVJLJQBGUITFLI

Associated Genomic Regions

Region: rs72795121

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.226
Position:
131638324
SE (Ratio):
0.022
Effect Allele:
A
Z-score (Ratio):
10.191
Reference Allele:
T
-log10(P):
-54.489
MAF:
0.475
Beta (Num):
0.101
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.125
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Histidine metabolism.6[1], 7[2]

Denominator Metabolite Explanation:

Fatty acid metabolism and transport.8[1], 9[2]

Ratio Explanation:

This ratio likely reflects the relative transport efficiency of hercynine and arachidoylcarnitine by the related and co-located transporters SLC22A4 and SLC22A5.10[1], 1[2], 11[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Variants in SLC22A4/SLC22A5 alter the transport of hercynine (antioxidant precursor) and carnitine (energy metabolism), affecting immune cell function and leading to inflammatory phenotypes like psoriatic arthropathy and asthma.12[1], 13[2], 14[3]

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data