dihomo-linoleate (20:2n6) to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs635619

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.174
Position:
131720265
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-11.122
Reference Allele:
G
-log10(P):
-64.496
MAF:
0.294
Beta (Num):
-0.045
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism5[1]

Denominator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle6[1], 7[2]

Ratio Explanation:

The ratio may reflect altered fatty acid metabolism, where decreased SLC22A5 function could reduce oleoylcarnitine production, while dihomo-linoleate levels are influenced by other pathways.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 transporter function likely decreases oleoylcarnitine levels, impacting fatty acid oxidation. This altered lipid metabolism may systemically affect hematopoietic cell counts, as carnitine metabolism is linked to hematopoietic stem cell function and can be disrupted during metabolic stress.8[1], 9[2], 10[3], 11[4], 12[5]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data