eicosapentaenoate (epa; 20:5n3) to linolenoylcarnitine (c18:3)*

Numerator Metabolite

Structure of eicosapentaenoate (epa; 20:5n3)
Metabolite Accession: GCST90200349
Name: eicosapentaenoate (epa; 20:5n3)
Hmdb Id: HMDB0001999
Super Pathway: NA
Sub Pathway: NA
Inchikey: JAZBEHYOTPTENJ

Denominator Metabolite

Structure of linolenoylcarnitine (c18:3)*
Metabolite Accession: GCST90200132
Name: linolenoylcarnitine (c18:3)*
Hmdb Id: HMDB0006469
Super Pathway: NA
Sub Pathway: NA
Inchikey: MJLXQSQYKZWZCB

Associated Genomic Regions

Region: rs149218

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.164
Position:
131669690
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-8.856
Reference Allele:
T
-log10(P):
-41.631
MAF:
0.373
Beta (Num):
-0.065
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.099
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Alpha-linolenic acid metabolism.4[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.5[1], 6[2]

Ratio Explanation:

The ratio of eicosapentaenoate to linolenoylcarnitine reflects the balance between omega-3 fatty acid availability and its subsequent carnitine-dependent mitochondrial transport for oxidation, modulated by SLC22A5.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SLC22A5 can impair carnitine transport, altering the ratio of omega-3 fatty acids (e.g., EPA) to their carnitine conjugates.1[1], 7[2] This dysfunction in fatty acid metabolism and energy production likely influences a range of systemic phenotypes, including hematological parameters and uric acid levels.8[3], 9[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data