glutamine conjugate of c6h10o2 (2)* to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs4705857

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Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.145
Position:
131737030
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-9.209
Reference Allele:
C
-log10(P):
-44.859
MAF:
0.313
Beta (Num):
-0.055
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.090
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 IRF1 P4HA2

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Glutamine conjugation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Ratio Explanation:

The ratio reflects carnitine transport efficiency via SLC22A5 relative to a glutamine conjugation product, indicating a balance between energy metabolism and detoxification pathways.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Genetic variation in the SLC22A5 locus alters carnitine transport, affecting palmitoleoylcarnitine levels. This change in cellular energy substrate availability may influence hematopoietic cell differentiation and proliferation, leading to the observed associations with monocyte and other white blood cell counts.8[1], 9[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data