docosadienoate (22:2n6) to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of docosadienoate (22:2n6)
Metabolite Accession: GCST90199711
Name: docosadienoate (22:2n6)
Hmdb Id: HMDB0061714
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVGRZDASOHMCSK

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs2631371

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.163
Position:
131703691
SE (Ratio):
0.016
Effect Allele:
A
Z-score (Ratio):
-10.070
Reference Allele:
G
-log10(P):
-53.244
MAF:
0.294
Beta (Num):
-0.034
Novel Locus:
No
SE (Num):
0.017
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/elongation.10[1], 11[2], 12[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.13[1], 14[2], 15[3], 16[4]

Ratio Explanation:

A decreased ratio suggests reduced oleoylcarnitine relative to docosadienoate, potentially indicating impaired carnitine-dependent fatty acid transport into mitochondria, influenced by SLC22A5 activity.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Impaired SLC22A5 function likely reduces oleoylcarnitine levels by hindering carnitine uptake required for its formation.1[1], 2[2], 3[3], 4[4], 5[5] This alteration in fatty acid metabolism may subsequently influence hematological traits like neutrophil and platelet counts, as observed in the BioBank Japan data.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data