oleate/vaccenate (18:1) to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs635619

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.119
Position:
131720265
SE (Ratio):
0.013
Effect Allele:
A
Z-score (Ratio):
-9.005
Reference Allele:
G
-log10(P):
-42.976
MAF:
0.293
Beta (Num):
-0.027
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.092
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis.4[1], 5[2], 6[3]

Denominator Metabolite Explanation:

Fatty acid oxidation.7[1], 8[2], 9[3]

Ratio Explanation:

This ratio reflects the efficiency of carnitine-dependent fatty acid transport into mitochondria, which is likely influenced by SLC22A5 carnitine transporter function.1[1], 10[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the SLC22A5 carnitine transporter likely alters fatty acid oxidation efficiency.11[1], 12[2] This impacts cellular energy balance, potentially affecting the proliferation and function of hematopoietic cells, leading to observed associations with various blood cell counts.13[3], 14[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data