3-hydroxyoleoylcarnitine to glutamine conjugate of c6h10o2 (2)*

Numerator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Denominator Metabolite

Metabolite Accession: GCST90200173
Name: glutamine conjugate of c6h10o2 (2)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs272849

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.158
Position:
131690241
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
10.314
Reference Allele:
G
-log10(P):
-55.761
MAF:
0.374
Beta (Num):
0.108
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.050
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism/oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Xenobiotic metabolism, Amino acid conjugation.

Ratio Explanation:

The ratio of a long-chain acylcarnitine to a glutamine conjugate may reflect SLC22A5 transporter activity influencing fatty acid oxidation versus alternative metabolic/detoxification pathways.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5 transporter function likely impacts carnitine-dependent energy metabolism in hematopoietic cells, leading to the observed changes in neutrophil, platelet, and other blood cell counts.6[1], 7[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data