docosadienoate (22:2n6) to acetylcarnitine (c2)

Numerator Metabolite

Structure of docosadienoate (22:2n6)
Metabolite Accession: GCST90199711
Name: docosadienoate (22:2n6)
Hmdb Id: HMDB0061714
Super Pathway: NA
Sub Pathway: NA
Inchikey: HVGRZDASOHMCSK

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs274546

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.148
Position:
131699867
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-10.006
Reference Allele:
G
-log10(P):
-52.597
MAF:
0.374
Beta (Num):
-0.036
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.112
SE (Den):
0.015
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis/metabolism.4[1], 5[2], 6[3], 7[4]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.8[1], 9[2], 10[3], 11[4]

Ratio Explanation:

The ratio reflects the balance between long-chain fatty acid availability (docosadienoate) and the capacity for their mitochondrial transport and oxidation, which depends on carnitine (acetylcarnitine precursor) uptake by SLC22A5.2[1], 8[2], 9[3]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Altered SLC22A5 function likely impairs carnitine-dependent fatty acid oxidation. This metabolic disruption could impact the development and function of hematopoietic cells, leading to the observed variations in monocyte, platelet, and other blood cell counts, as well as influencing uric acid levels through altered cellular metabolism.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data