oleate/vaccenate (18:1) to oleoylcarnitine (c18:1)

Numerator Metabolite

Structure of oleate/vaccenate (18:1)
Metabolite Accession: GCST90200042
Name: oleate/vaccenate (18:1)
Hmdb Id: HMDB0003231,HMDB0000573,HMDB0240219,HMDB0000207
Super Pathway: NA
Sub Pathway: NA
Inchikey: UWHZIFQPPBDJPM

Denominator Metabolite

Metabolite Accession: GCST90199774
Name: NA
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Associated Genomic Regions

Region: rs635619

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.157
Position:
131720265
SE (Ratio):
0.015
Effect Allele:
A
Z-score (Ratio):
-10.386
Reference Allele:
G
-log10(P):
-56.506
MAF:
0.293
Beta (Num):
-0.027
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.129
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 P4HA2 IRF1

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, beta-oxidation.4[1], 5[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine shuttle.6[1], 7[2]

Ratio Explanation:

The ratio of oleate to its carnitine conjugate (oleoylcarnitine) reflects the rate of carnitine-dependent fatty acid transport into mitochondria for beta-oxidation.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function likely impairs carnitine transport into cells, including immune cells, decreasing fatty acid oxidation.1[1], 8[2] This metabolic shift may alter immune cell function and counts, leading to the observed hematological phenotypes like changes in monocyte and lymphocyte counts.8[3]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data