dihomo-linolenate (20:3n3 or n6) to 3-hydroxyoleoylcarnitine

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of 3-hydroxyoleoylcarnitine
Metabolite Accession: GCST90200158
Name: 3-hydroxyoleoylcarnitine
Hmdb Id: HMDB0240761
Super Pathway: NA
Sub Pathway: NA
Inchikey: YBCVTTMMURGSEY

Associated Genomic Regions

Region: rs10076701

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.160
Position:
131596419
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-9.764
Reference Allele:
C
-log10(P):
-50.183
MAF:
0.445
Beta (Num):
-0.042
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.119
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
PDLIM4 P4HA2 SLC22A4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid biosynthesis, eicosanoid metabolism.5[1], 6[2], 7[3]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, carnitine transport.8[1], 9[2], 10[3]

Ratio Explanation:

This ratio reflects the balance between a free fatty acid (dihomo-linolenate) and its incompletely oxidized product, modulated by carnitine transport via SLC22A5.2[1], 11[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in SLC22A4/A5 alter transporter function, impacting both fatty acid metabolism (the ratio) and, for SLC22A4, renal urate transport. This dual effect provides a link to gout and associated changes in serum uric acid and creatinine.12[1], 13[2], 14[3], 15[4]

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data