dihomo-linolenate (20:3n3 or n6) to myristoylcarnitine (c14)

Numerator Metabolite

Structure of dihomo-linolenate (20:3n3 or n6)
Metabolite Accession: GCST90199820
Name: dihomo-linolenate (20:3n3 or n6)
Hmdb Id: HMDB0002925
Super Pathway: NA
Sub Pathway: NA
Inchikey: AHANXAKGNAKFSK

Denominator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Associated Genomic Regions

Region: rs272880

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.169
Position:
131670178
SE (Ratio):
0.018
Effect Allele:
C
Z-score (Ratio):
-9.548
Reference Allele:
T
-log10(P):
-48.073
MAF:
0.294
Beta (Num):
-0.053
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
0.116
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 SLC22A5 P4HA2 PDLIM4 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Polyunsaturated fatty acid biosynthesis.3[1], 4[2]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.5[1], 6[2]

Ratio Explanation:

This ratio reflects the balance between polyunsaturated fatty acid synthesis (FADS1/2 activity) and fatty acid oxidation requiring carnitine transported by SLC22A5.1[1], 7[2], 3[3], 5[4]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variation in the FADS gene cluster alters fatty acid profiles, impacting inflammatory responses and lipid metabolism, which contributes to phenotypes like dermatitis and thrombophlebitis.8[1], 9[2], 10[3]

Phenotype Driver:

Gene-centric:FADS1

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data