dihomo-linoleate (20:2n6) to myristoleoylcarnitine (c14:1)*

Numerator Metabolite

Structure of dihomo-linoleate (20:2n6)
Metabolite Accession: GCST90200320
Name: dihomo-linoleate (20:2n6)
Hmdb Id: HMDB0005060
Super Pathway: NA
Sub Pathway: NA
Inchikey: XSXIVVZCUAHUJO

Denominator Metabolite

Structure of myristoleoylcarnitine (c14:1)*
Metabolite Accession: GCST90199979
Name: myristoleoylcarnitine (c14:1)*
Hmdb Id: HMDB0240588
Super Pathway: NA
Sub Pathway: NA
Inchikey: ABVVZYXTZLEOHP

Associated Genomic Regions

Region: rs274572

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

Loading Ratio Plot...

Loading Numerator Plot...

Loading Denominator Plot...

SNP Summary

Chr:
5
Beta (Ratio):
-0.118
Position:
131710917
SE (Ratio):
0.014
Effect Allele:
G
Z-score (Ratio):
-8.213
Reference Allele:
T
-log10(P):
-36.074
MAF:
0.294
Beta (Num):
-0.045
Novel Locus:
Yes ✔️
SE (Num):
0.017
Beta (Den):
0.073
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 SLC22A4 C5orf56 P4HA2 PDLIM4

LLM Analysis

Numerator Metabolite Explanation:

Linoleic acid metabolism

Denominator Metabolite Explanation:

Fatty acid beta-oxidation, Carnitine shuttle

Ratio Explanation:

An increased ratio of dihomo-linoleate to myristoleoylcarnitine may suggest impaired SLC22A5 function, reducing carnitine-dependent fatty acid transport relative to other circulating fatty acids.

Ratio Evidence:

metabolites not in a pathway but enzyme catalyzes one metabolite

Gene Ratio Phenotype Relationship:

Reduced SLC22A5 function alters carnitine-dependent fatty acid metabolism, a process crucial for various cell types.1[1], 4[2] This systemic metabolic disruption can impact hematopoiesis, leading to observed changes in monocyte, platelet, and white blood cell counts.5[3], 6[4]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data