cerotoylcarnitine (c26)* to tryptophan betaine

Numerator Metabolite

Structure of cerotoylcarnitine (c26)*
Metabolite Accession: GCST90200136
Name: cerotoylcarnitine (c26)*
Hmdb Id: HMDB0006347
Super Pathway: NA
Sub Pathway: NA
Inchikey: KOCKWDDTAHPJSX

Denominator Metabolite

Structure of tryptophan betaine
Metabolite Accession: GCST90199819
Name: tryptophan betaine
Hmdb Id: HMDB0061115
Super Pathway: NA
Sub Pathway: NA
Inchikey: AOHCBEAZXHZMOR

Associated Genomic Regions

Region: rs11743851

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.189
Position:
130613600
SE (Ratio):
0.020
Effect Allele:
C
Z-score (Ratio):
-9.605
Reference Allele:
T
-log10(P):
-48.629
MAF:
0.382
Beta (Num):
-0.095
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.094
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
CDC42SE2 LYRM7 HINT1 RAPGEF6 CTC-432M15.3

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation.23[1], 24[2]

Denominator Metabolite Explanation:

Tryptophan metabolism.26[1], 27[2]

Ratio Explanation:

The ratio reflects altered transport activity by SLC22A4/A5, affecting both very-long-chain fatty acid metabolism (cerotoylcarnitine) and potentially the anti-inflammatory metabolite tryptophan betaine.13[1], 27[2]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants in *SLC22A4* and *SLC22A5* are associated with inflammatory bowel disease (IBD).18[1], 20[2] Altered function of these transporters, which move carnitine and other organic cations, likely drives metabolic changes, including this ratio, contributing to the inflammatory phenotype seen in IBD.1[3], 22[4], 18[5]

Phenotype Driver:

Gene-centric:SLC22A4

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data