hexadecadienoate (16:2n6) to acetylcarnitine (c2)

Numerator Metabolite

Structure of hexadecadienoate (16:2n6)
Metabolite Accession: GCST90200104
Name: hexadecadienoate (16:2n6)
Hmdb Id: HMDB0000477
Super Pathway: NA
Sub Pathway: NA
Inchikey: WPJGPAAPSBVXNU

Denominator Metabolite

Structure of acetylcarnitine (c2)
Metabolite Accession: GCST90199669
Name: acetylcarnitine (c2)
Hmdb Id: HMDB0000201
Super Pathway: NA
Sub Pathway: NA
Inchikey: RDHQFKQIGNGIED

Associated Genomic Regions

Region: rs419291

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.153
Position:
131633355
SE (Ratio):
0.016
Effect Allele:
T
Z-score (Ratio):
-9.892
Reference Allele:
C
-log10(P):
-51.451
MAF:
0.372
Beta (Num):
-0.041
Novel Locus:
No
SE (Num):
0.015
Beta (Den):
0.112
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid beta-oxidation

Denominator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle4[1], 5[2], 6[3]

Ratio Explanation:

The ratio of hexadecadienoate to acetylcarnitine reflects carnitine-dependent fatty acid oxidation efficiency, which is modulated by the SLC22A5 carnitine transporter.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Genetic variants near SLC22A5, a carnitine transporter, alter its function, impacting carnitine-dependent fatty acid oxidation.1[1], 7[2] This metabolic disruption likely affects energy homeostasis in hematopoietic and immune cells, leading to observed variations in neutrophil, platelet, and other blood cell counts.8[3], 9[4], 10[5]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data