myristoylcarnitine (c14) to palmitate (16:0)

Numerator Metabolite

Structure of myristoylcarnitine (c14)
Metabolite Accession: GCST90199730
Name: myristoylcarnitine (c14)
Hmdb Id: HMDB000506
Super Pathway: NA
Sub Pathway: NA
Inchikey: PSHXNVGSVNEJBD

Denominator Metabolite

Structure of palmitate (16:0)
Metabolite Accession: GCST90200397
Name: palmitate (16:0)
Hmdb Id: HMDB0000220
Super Pathway: NA
Sub Pathway: NA
Inchikey: IPCSVZSSVZVIGE

Associated Genomic Regions

Region: rs270612

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
0.153
Position:
131637338
SE (Ratio):
0.016
Effect Allele:
G
Z-score (Ratio):
9.632
Reference Allele:
A
-log10(P):
-48.887
MAF:
0.293
Beta (Num):
0.117
Novel Locus:
No
SE (Num):
0.016
Beta (Den):
-0.036
SE (Den):
0.017
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A4 P4HA2 PDLIM4 SLC22A5 C5orf56

LLM Analysis

Numerator Metabolite Explanation:

Fatty acid metabolism, carnitine shuttle

Denominator Metabolite Explanation:

Fatty acid biosynthesis4[1], 5[2], 6[3]

Ratio Explanation:

An elevated ratio of myristoylcarnitine to palmitate may indicate altered fatty acid metabolism, potentially due to impaired carnitine transport by SLC22A5.

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired SLC22A5 function could alter fatty acid availability and energy metabolism, impacting hematopoietic cell production and differentiation, leading to observed changes in blood cell counts and height.

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data