glutamine conjugate of c6h10o2 (1)* to palmitoleoylcarnitine (c16:1)*

Numerator Metabolite

Metabolite Accession: GCST90200176
Name: glutamine conjugate of c6h10o2 (1)*
Hmdb Id: NA
Super Pathway: NA
Sub Pathway: NA
Inchikey: NA

Denominator Metabolite

Structure of palmitoleoylcarnitine (c16:1)*
Metabolite Accession: GCST90200110
Name: palmitoleoylcarnitine (c16:1)*
Hmdb Id: HMDB0240782
Super Pathway: NA
Sub Pathway: NA
Inchikey: JFAGPSOZZSTLRF

Associated Genomic Regions

Region: rs4705857

Click a 'Plot' button in the tables to the right to view a locus plot here.

Clumped rQTL variant

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SNP Summary

Chr:
5
Beta (Ratio):
-0.153
Position:
131737030
SE (Ratio):
0.018
Effect Allele:
T
Z-score (Ratio):
-8.721
Reference Allele:
C
-log10(P):
-40.428
MAF:
0.312
Beta (Num):
-0.063
Novel Locus:
Yes ✔️
SE (Num):
0.016
Beta (Den):
0.090
SE (Den):
0.016
No CNV overlap
rQTL cluster:
115
Reaction Distance:
NA
Closest Genes:
SLC22A5 C5orf56 SLC22A4 IRF1 P4HA2

LLM Analysis

Numerator Metabolite Explanation:

Xenobiotic metabolism, Fatty acid omega-oxidation.5[1]

Denominator Metabolite Explanation:

Fatty acid beta-oxidation.6[1], 7[2]

Ratio Explanation:

This ratio may reflect impaired beta-oxidation due to deficient carnitine transport via SLC22A5, affecting both beta- and omega-oxidation pathway intermediates.1[1]

Ratio Evidence:

metabolites related through biology

Gene Ratio Phenotype Relationship:

Impaired carnitine transport due to SLC22A5 variants alters fatty acid metabolism, which is crucial for the function and inflammatory responses of immune cells like monocytes and neutrophils, thus affecting their counts in the blood.8[1], 9[2]

Phenotype Driver:

Gene-centric:SLC22A5

Downloads

Download the full rQTL summary statistics file for this metabolite ratio. Data contains the loci listed here. For each SNP (chromosome, effect_allele, reference_allele, pos_name, position) these columns contain the summary statistics of the ratio (beta, pgain, pval, se, z), the numerator metabolite (beta_1, pval_1, n_iids_1, effect_allele_frequency_1, se_1, z_1) and the denominator metabolite (beta_2, pval_2, n_iids_2, effect_allele_frequency_2, se_2, z_2)

Download rQTL Data